Eurasia Research Quarterly Newsletter HBSRA (January 2020 - March 2020)
Updated: Mar 23, 2020
Dear HBSRA Members,
Greetings and sincere thanks for your patronage and support. HBSRA has now grown to 5210 followers and members from 54 countries.
We are glad to present you our latest edition of the newsletter. The newsletter showcases the associations of current and upcoming endeavors.
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Eurasia Research International Conference began with opening remarks by Honourable Keynote speaker highlighting the main context on Health Issues. The main aim of this conference was:
The main aim of this conference was:
Advancement of academic knowledge through encouraging research activities.
To create a global community of scholars
Promotion of innovative thinking and ideas on a global platform
Making knowledge accessible to one and all using technology and ideas
Contributing to making the world a better place to live
Our worthy Keynote speakers open up the conference enlightening participants with their speech. Here is our list of keynote speakers who participated in our conference.
Dr. Saadia Khouyibaba
Senior Instructor, American University of Sharjah, U.A.E.
Dr. Holger Nord
Area Manager, Victorian School of Languages, Australia
Dr. W. G. Samanthi Konarasinghe
Institute of Mathematics and Management, Ranala, Sri Lanka
Eurasia Research makes continuous efforts in transforming the lives of people around the world through education, application of research & innovative ideas. In order to Promote Young Researchers, Eurasia Research International conferences, Provides Young Research Scholarship in the form of a full Registration fee waiver to participate in such events. This gives immense encouragement to the researchers who have brilliant ideas to exhibit their research work on the International platform. Eurasia Research aims for promoting research and talent of scholars by giving the scholarship to 5 selected applicants for each conference.
Name of Person Attending: Saleha Anwar
Affiliation: Ph.D. Scholar, Jamia Millia Islamia University, India
Paper Title: Investigation of the inhibitory potential of Quercetin to the pyruvate dehydrogenase kinase 3 towards implications in anticancer therapy.
Abstract: Pyruvate dehydrogenase kinase 3 (PDK3) is a mitochondrial protein, has recently been considered as a potential pharmacological target for varying types of cancer. Here, we report the binding mechanism of quercetin to the PDK3 by using molecular docking, simulation, ﬂuorescence spectroscopy, and isothermal titration calorimetric assays. Molecular docking along with simulation provided an in-depth analysis of protein-ligand interactions. We have observed that quercetin interacts with the important residues of the active site cavity of PDK3 and shows a well- ordered conformational ﬁtting. The stability of the quercetin-PDK3 complex is maintained by several non-covalent interactions throughout the simulation. To complement in silico ﬁndings with the experiments, we have successfully expressed and puriﬁed human PDK3. Both ﬂuorescence and isothermal titration calorimetric experiments showed excellent binding afﬁnity of quercetin to the PDK3. Kinase inhibition assay further revealed a signiﬁcant inhibitory potential of quercetin to the PDK3 with the IC50 values in the μM range. Quercetin is non-toxic to HEK293, and signiﬁcantly inhibits the proliferation of cancer (HepG2 and A549) cell lines. All these observations clearly indicate that quercetin may be further evaluated as a promising therapeutic molecule for PDK3 with required mod- iﬁcations and in vivo validation.
In each, Eurasia International Conference, Best Paper Award is given to Best Researches. In the Healthcare & Biological Sciences Research Association (HBSRA), the Best paper award is given to the participants with the best scholarly paper submitted and presented at the conference.
Name of Persons Attending: Tariq Chaudhry & Waheed Ahmad Baig
Affiliation: Science Department, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia
Paper Title: Synergistic Anti-Cancer Effects of Nigella Sativa Seed Oil and Conventional Cytotoxic Agent against Human Breast Cancer
Abstract: Breast cancer is the most frequently diagnosed invasive non-skin malignancy and the leading cause of cancer-related deaths in women throughout the world. Scientific research has shown that black seed oil (Nigella sativa) is an effective treatment for cancer in animal studies, and as effective as anti-cancer effects on some other types of cancer.
This study aimed to investigate possible synergistic cytotoxic effects of Nigella Sativa Seed Oil in combination with a conventional cytotoxic agent (doxorubicin) for the treatment of human breast cancer cells.
Human breast cancer cells (MCF-7) were treated with Nigella Sativa seed oil either alone or in combination with doxorubicin to investigate the effect of the treatment. Cell proliferation and viability were analyzed by 3-(4,5-dimethylthiazol-2yl)-2,5-biphenyl tetrazolium bromide (MTT) and cell proliferation assays, and cellular morphology by phase-contrast inverted microscopy. Furthermore, the role of Nigella Sativa seed oil in decreasing cell tumorigenicity features by testing the cancer cell migration using a wound-healing assay.
Results showed that higher concentrations (50µg/ml) of Nigella Sativa seed oil changed the breast cancer cell morphology and decreased cell proliferation and viability. We also found that breast cancer cells treated with black seed oil decreased the cell movement after 24 hours compared to the untreated cell as evident by wound healing assay. Only the higher concentration of doxorubicin (0.5µg/ml-2.5µg/ml) reduced cell proliferation and cell viability. Moreover, the combination treatment of 50ug/ml of Black seed oil with different concentrations of doxorubicin caused a significant cell reduction and decreased viability with lower concentration (0.1µg /ml) of doxorubicin.
In conclusion, Nigella Sativa Seed Oil alone oil or in combination with doxorubicin was found to synergistically decreasing the cell proliferation and cell viability of MCF-7 breast cancer cells in a dose-dependent manner, unveiling promising opportunities in the field of cancer treatment.
Keywords: Breast Cancer, Nigella Sativa, Doxorubicin Synergetic, Anti-cancer
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Referencing and DOI by CROSSREF, Membership Prefix (10.20319)
ROAD: Directory of Open Access Scholarly Resources
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